Endocrine Abstracts

Introduction: Cushing’s disease (CD) leads to glucose homeostasis alterations, obesity, unfavorable changes in body composition and cardiovascular complications.Aim of study: i) Prospective evaluation of the frequency of pre-diabetes and diabetes. ii) Assessment of insulin resistance (IR) indices in CD. iii) Analysis of the influence of family history of type 2 diabetes (T2D) on the anthropometry in CD.Methods: The study group...

Introduction: Generously supported by IPSEN)-->ACTH-secreting pituitary adenomas are the most common cause of endogenous hypercortisolemia in children after 10 years of age. In spite of this pediatric Cushing’s disease (pCD) is a rare medical condition. Transsphenoidal surgery (TSS) remains the treatment of choice but – according to literature date – results of such a procedure could be worse comparatively to adult pop...

Introduction: Generously supported by IPSEN)-->Acromegaly is associated with increased morbidity and mortality, mainly due to cardiovascular and metabolic complications and higher risk of malignancy. The treatment of choice is selective transsphenoidal surgery (TSS). Successful removal of somatotroph adenoma normalizes GH and IGF1 levels, which improves the patients prognosis. The efficacy of TSS depends on the tumor volume, parasell...

Introduction: Cortisol excess in Cushing’s disease (CD) leads to glucose homeostasis alterations and increased cardiovascular risk.Aim of the study: i) To assess the reversibility of glucose homeostasis alterations and dynamics of inflammatory and coagulation parameters after the successful transsphenoidal surgery (TSS) for CD. ii) Analysis of the early improvement in insulin resistance (IR) indices following TSS.Methods: The ...

Background: Craniopharyngiomas may lead to pituitary insufficiency and neurological symptoms. However the rate of the tumor growth and the time of developing hypopituitarism are difficult to predict.Case report: A 68-year-old male of short stature (height 148 cm) was admitted to the area hospital due to loss of consciousness. The acute coronary syndrome and stroke had been excluded but laboratory tests showed hyponatremia of 106 mmol/l. Hormone measureme...

Introduction: Effective surgical treatment of Cushing’s disease (CD) is associated with a rapid decrease in the serum cortisol concentration, which requires the introduction of the hydrocortisone replacement treatment. However, the time of restoration of adrenal function is difficult to predict. The aim of the study was to evaluate the dynamics of serum cortisol concentrations after successful transsphenoidal surgery and to determine the time to restore the function of th...

Introduction: Pituitary apoplexy is a life-threatening entity developing as a result of ischemia or hemorrhage into pre-existing pituitary tumor. Clinical course is characteristic and commonly consists of severe headache accompanied by nausea, emesis, impaired consciousness, visual field impairment as well as eyeballs movement restriction. Symptoms are typically accompanied by secondary adrenal insufficiency. Corticosteroids are drugs of choice regarding coexisting adrenal ins...

Background: Cortisol excess in Cushing’s disease (CD) leads to metabolic complications, thromboembolic events, and increased cardiovascular risk. The aim of this study was to assess the reversibility of glucose homeostasis alterations and dynamics of inflammatory and coagulation parameters following the successful transsphenoidal surgery.Methods: The group consisted of 14 patients with CD (11 females; age: 41.5±14.5) operated on according to th...

Nelson’s syndrome (NS) is a rare clinical syndrome of an enlarging, aggresive corticotroph pituitary adenoma that can occur following bilateral adrenalectomy performed in the treatment of CD.The aim of this work is the evaluation of the early and long-term results of the microsurgery in a single surgeon’s series of patients with NSDuring the period from January 2000 to December 2005 - ten patients with NS have been operat...

Isolated sarcoidosis of the hypothalamic-pituitary system is a very rare form of neurosarcoidosis. It usually leads to secondary damage to endocrine function, resulting in hypopituitarism and diabetes insipidus. A 32-year-old male patient with progressive deterioration of his general condition, weakness, polyuria, dizziness and visual field disturbances was admitted to the Department of Endocrinology for the diagnosis of a tumor in the hypothalamic-pituitary region. MRI showed...